This article focuses on institutional and policy innovation in two Hungarian regions. We analyse the responses of the local elites in these two regions to the post- 1989 challenges and discuss how they have tried to innovate local economic policy in order to promote economic development. Also, we will consider to what extent they have been constrained or facilitated by historically developed institutions. We conclude that the more successful innovation strategies have been those which have at least partially been based on historically accumulated institutional resources. These have been selectively employed in innovative ways and form essential building blocks of the regions' new development strategies. Also, the cases suggest that economic development, as well as the accumulation of institutional resources over time, do not necessarily follow one homogeneous path but may combine several simultaneous paths. Different combinations, then, result in diverse sets of institutional resources which affect the capacity for innovation.