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dc.contributor.authorBENDER, Andrew R.
dc.contributor.authorKERESZTES, Attila
dc.contributor.authorBODAMMER, Nils C.
dc.contributor.authorSHING, Yee Lee
dc.contributor.authorWERKLE-BERGNER, Markus
dc.contributor.authorDAUGHERTY, Ana M.
dc.contributor.authorYU, Qijing
dc.contributor.authorKUEHN, Simone
dc.contributor.authorLINDENBERGER, Ulman 
dc.contributor.authorRAZ, Naftali
dc.date.accessioned2018-12-06T13:55:53Z
dc.date.available2018-12-06T13:55:53Z
dc.date.issued2018
dc.identifier.citationHuman brain mapping, 2018, Vol. 39, No. 2, pp. 916-931
dc.identifier.issn1065-9471
dc.identifier.issn1097-0193en
dc.identifier.urihttp://hdl.handle.net/1814/60007
dc.descriptionFirst published: 23 November 2017en
dc.description.abstractAutomated segmentation of hippocampal (HC) subfields from magnetic resonance imaging (MRI) is gaining popularity, but automated procedures that afford high speed and reproducibility have yet to be extensively validated against the standard, manual morphometry. We evaluated the concurrent validity of an automated method for hippocampal subfields segmentation (automated segmentation of hippocampal subfields, ASHS Yushkevich et al., 2015b) using a customized atlas of the HC body, with manual morphometry as a standard. We built a series of customized atlases comprising the entorhinal cortex (ERC) and subfields of the HC body from manually segmented images, and evaluated the correspondence of automated segmentations with manual morphometry. In samples with age ranges of 6-24 and 62-79 years, 20 participants each, we obtained validity coefficients (intraclass correlations, ICC) and spatial overlap measures (dice similarity coefficient) that varied substantially across subfields. Anterior and posterior HC body evidenced the greatest discrepancies between automated and manual segmentations. Adding anterior and posterior slices for atlas creation and truncating automated output to the ranges manually defined by multiple neuroanatomical landmarks substantially improved the validity of automated segmentation, yielding ICC above 0.90 for all subfields and alleviating systematic bias. We cross-validated the developed atlas on an independent sample of 30 healthy adults (age 31-84) and obtained good to excellent agreement: ICC (2) = 0.70-0.92. Thus, with described customization steps implemented by experts trained in MRI neuroanatomy, ASHS shows excellent concurrent validity, and can become a promising method for studying age-related changes in HC subfield volumes.
dc.description.sponsorshipDeutsche Forschungsgemeinschaft [WE 4269/2-1]
dc.description.sponsorshipJacobs Foundation
dc.description.sponsorshipNational Institute on Aging, USA [R01 AG011230]
dc.language.isoen
dc.relation.ispartofHuman brain mapping
dc.subjectAging
dc.subjectDevelopment
dc.subjectHippocampus
dc.subjectMRI
dc.subjectMorphometry
dc.subjectValidation
dc.subjectVolume
dc.subjectHigh-resolution mrien
dc.subjectIn-vivo mrien
dc.subjectEntorhinal cortexen
dc.subjectParahippocampal subregionsen
dc.subjectVascular risken
dc.subjectBrain imagesen
dc.subjectAgeen
dc.subjectProtocolen
dc.subjectVolumesen
dc.subjectMemoryen
dc.titleOptimization and validation of automated hippocampal subfield segmentation across the lifespan
dc.typeArticleen
dc.identifier.doi10.1002/hbm.23891
dc.identifier.volume39
dc.identifier.startpage916
dc.identifier.endpage931
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