Self-rated intensity of habitual physical activities is positively associated with dopamine D-2/3 receptor availability and cognition

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dc.contributor.authorKOEHNCKE, Ylva
dc.contributor.authorPAPENBERG, Goran
dc.contributor.authorJONASSON, Lars
dc.contributor.authorKARALIJA, Nina
dc.contributor.authorWAHLIN, Anders
dc.contributor.authorSALAMI, Alireza
dc.contributor.authorANDERSSON, Micael
dc.contributor.authorAXELSSON, Jan
dc.contributor.authorNYBERG, Lars
dc.contributor.authorRIKLUND, Katrine
dc.contributor.authorBACKMAN, Lars
dc.contributor.authorLINDENBERGER, Ulman
dc.contributor.authorLOVDEN, Martin
dc.date.accessioned2018-12-06T13:55:27Z
dc.date.available2018-12-06T13:55:27Z
dc.date.issued2018
dc.descriptionAvailable online: 21 July 2018en
dc.description.abstractBetween-person differences in cognitive performance in older age are associated with variations in physical activity. The neurotransmitter dopamine (DA) contributes to cognitive performance, and the DA system deteriorates with advancing age. Animal data and a patient study suggest that physical activity modulates DA receptor availability, but data from healthy humans are lacking. In a cross-sectional study with 178 adults aged 64-68 years, we investigated links among self-reported physical activity, D(2/3)DA receptor (D2/3DR) availability, and cognitive performance. D2/3DR availability was measured with [C-11]raclopride positron emission tomography at rest. We used structural equation modeling to obtain latent factors for processing speed, episodic memory, working memory, physical activity, and D2/3DR availability in caudate, putamen, and hippocampus. Physical activity intensity was positively associated with D2/3DR availability in caudate, but not putamen and hippocampus. Frequency of physical activity was not related to D2/3DR availability. Physical activity intensity was positively related to episodic memory and working memory. D2/3DR availability in caudate and hippocampus was positively related to episodic memory. Taken together, our results suggest that striatal DA availability might be a neurochemical correlate of episodic memory that is also associated with physical activity.
dc.description.sponsorshipSwedish Research Council [446-2013-7189]
dc.description.sponsorshipFORTE [2013-2277]
dc.description.sponsorshipUmea University
dc.description.sponsorshipUmea University-Karolinska Institute Strategic Neuroscience program
dc.description.sponsorshipKnut and Alice Wallenberg Foundation
dc.description.sponsorshipgs5:Torsten and Ragnar Soderberg Foundation
dc.description.sponsorshipAlexander von Humboldt Research award
dc.description.sponsorshipSwedish Brain Power
dc.description.sponsorshipSwedish Brain Foundation
dc.description.sponsorshipVasterbotten County Council
dc.description.sponsorshipMax Planck Society
dc.description.sponsorshipGerman Research Foundation (DFG)
dc.identifier.citationNeuroimage, 2018, Vol. 181, pp. 605-616
dc.identifier.doi10.1016/j.neuroimage.2018.07.036
dc.identifier.endpage616
dc.identifier.issn1053-8119
dc.identifier.issn1095-9572en
dc.identifier.startpage605
dc.identifier.urihttps://hdl.handle.net/1814/59953
dc.identifier.volume181
dc.language.isoen
dc.publisherElsevieren
dc.relation.ispartofNeuroimage
dc.subjectCognition
dc.subjectEpisodic memory
dc.subjectDopamine
dc.subjectPhysical activity
dc.subjectAging
dc.subjectRandomized controlled-trialen
dc.subjectWhite-matter integrityen
dc.subjectAge-related declineen
dc.subjectOlder-adultsen
dc.subjectAerobic exerciseen
dc.subjectEpisodic memoryen
dc.subjectParkinsons-diseaseen
dc.subjectD2 receptoren
dc.subjectHuman brainen
dc.subjectTreadmill exerciseen
dc.titleSelf-rated intensity of habitual physical activities is positively associated with dopamine D-2/3 receptor availability and cognition
dc.typeArticleen
dspace.entity.typePublication
eui.subscribe.skiptrue
person.identifier.other38986
relation.isAuthorOfPublication3083549e-a7e1-414b-aa98-1b5b208c2f10
relation.isAuthorOfPublication.latestForDiscovery3083549e-a7e1-414b-aa98-1b5b208c2f10
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