Latent-profile analysis reveals behavioral and brain correlates of dopamine-cognition associations
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1047-3211; 1460-2199
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Cognitive performance; Dopamine D-2/3 receptor availability; Heterogeneity; Latent profile analysis; Older adults; Working memory; Catechol-o-methyltransferase; Positron-emission-tomography; D2 receptor availability; Age-related decline; Working-memory; Prefrontal cortex; Functional connectivity; In-vivo; Bipolar disorder; Individual differences
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Cerebral cortex, 2018, Vol. 28, No. 11, pp. 3894–3907
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LOVDEN, Martin, KARALIJA, Nina, ANDERSSON, Micael, WAHLIN, Anders, AXELSSON, Jan, KOHNCKE, Ylva, JONASSON, Lars, RIECKMAN, Anna, PAPENBERG, Goran, GARRETT, Douglas D., GUITART-MASIP, Marc, SALAMI, Alireza, RIKLUND, Katrine, BACKMAN, Lars, NYBERG, Lars, LINDENBERGER, Ulman, Latent-profile analysis reveals behavioral and brain correlates of dopamine-cognition associations, Cerebral cortex, 2018, Vol. 28, No. 11, pp. 3894–3907 - https://hdl.handle.net/1814/59952
Abstract
Evidence suggests that associations between the neurotransmitter dopamine and cognition are nonmonotonic and open to modulation by various other factors. The functional implications of a given level of dopamine may therefore differ from person to person. By applying latent-profile analysis to a large (n = 181) sample of adults aged 64-68 years, we probabilistically identified 3 subgroups that explain the multivariate associations between dopamine D2/3R availability (probed with C-11-raclopride-PET, in cortical, striatal, and hippocampal regions) and cognitive performance (episodic memory, working memory, and perceptual speed). Generally, greater receptor availability was associated with better cognitive performance. However, we discovered a subgroup of individuals for which high availability, particularly in striatum, was associated with poor performance, especially for working memory. Relative to the rest of the sample, this subgroup also had lower education, higher body-mass index, and lower resting-state connectivity between caudate nucleus and dorsolateral prefrontal cortex. We conclude that a smaller subset of individuals induces a multivariate non-linear association between dopamine D2/3R availability and cognitive performance in this group of older adults, and discuss potential reasons for these differences that await further empirical scrutiny.
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Published: 25 September 2017
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Swedish Research Council [446-2013-7189] et al.