Date: 2018
Type: Article
Latent-profile analysis reveals behavioral and brain correlates of dopamine-cognition associations
Cerebral cortex, 2018, Vol. 28, No. 11, pp. 3894–3907
LOVDEN, Martin, KARALIJA, Nina, ANDERSSON, Micael, WAHLIN, Anders, AXELSSON, Jan, KOHNCKE, Ylva, JONASSON, Lars, RIECKMAN, Anna, PAPENBERG, Goran, GARRETT, Douglas D., GUITART-MASIP, Marc, SALAMI, Alireza, RIKLUND, Katrine, BACKMAN, Lars, NYBERG, Lars, LINDENBERGER, Ulman, Latent-profile analysis reveals behavioral and brain correlates of dopamine-cognition associations, Cerebral cortex, 2018, Vol. 28, No. 11, pp. 3894–3907
- https://hdl.handle.net/1814/59952
Retrieved from Cadmus, EUI Research Repository
Evidence suggests that associations between the neurotransmitter dopamine and cognition are nonmonotonic and open to modulation by various other factors. The functional implications of a given level of dopamine may therefore differ from person to person. By applying latent-profile analysis to a large (n = 181) sample of adults aged 64-68 years, we probabilistically identified 3 subgroups that explain the multivariate associations between dopamine D2/3R availability (probed with C-11-raclopride-PET, in cortical, striatal, and hippocampal regions) and cognitive performance (episodic memory, working memory, and perceptual speed). Generally, greater receptor availability was associated with better cognitive performance. However, we discovered a subgroup of individuals for which high availability, particularly in striatum, was associated with poor performance, especially for working memory. Relative to the rest of the sample, this subgroup also had lower education, higher body-mass index, and lower resting-state connectivity between caudate nucleus and dorsolateral prefrontal cortex. We conclude that a smaller subset of individuals induces a multivariate non-linear association between dopamine D2/3R availability and cognitive performance in this group of older adults, and discuss potential reasons for these differences that await further empirical scrutiny.
Additional information:
Published: 25 September 2017
Cadmus permanent link: https://hdl.handle.net/1814/59952
Full-text via DOI: 10.1093/cercor/bhx253
ISSN: 1047-3211; 1460-2199
Publisher: Oxford University Press
Keyword(s): Cognitive performance Dopamine D-2/3 receptor availability Heterogeneity Latent profile analysis Older adults Working memory Catechol-o-methyltransferase Positron-emission-tomography D2 receptor availability Age-related decline Working-memory Prefrontal cortex Functional connectivity In-vivo Bipolar disorder Individual differences
Sponsorship and Funder information:
Swedish Research Council [446-2013-7189] et al.
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