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dc.contributor.authorKLEEMEYER, Maike M.
dc.contributor.authorKUEHN, Simone
dc.contributor.authorPRINDLE, John J.
dc.contributor.authorBODAMMER, Nils C.
dc.contributor.authorBRECHTEL, Lars
dc.contributor.authorGARTHE, Alexander
dc.contributor.authorKEMPERMANN, Gerd
dc.contributor.authorSCHAEFER, Sabine
dc.contributor.authorLINDENBERGER, Ulman
dc.date.accessioned2019-03-01T14:53:39Z
dc.date.available2019-03-01T14:53:39Z
dc.date.issued2016
dc.identifier.citationNeuroimage, 2016, Vol. 131, pp. 155-161
dc.identifier.issn1053-8119
dc.identifier.issn1095-9572en
dc.identifier.urihttps://hdl.handle.net/1814/61491
dc.description.abstractThis study investigates the effects of fitness changes on hippocampal microstructure and hippocampal volume. Fifty-two healthy participants aged 59-74 years with a sedentary lifestyle were randomly assigned to either of two levels of exercise intensity. Training lasted for six months. Physical fitness, hippocampal volumes, and hippocampal microstructure were measured before and after training. Hippocampal microstructure was assessed by mean diffusivity, which inversely reflects tissue density
dc.description.abstracthence, mean diffusivity is lower for more densely packed tissue. Mean changes in fitness did not differ reliably across intensity levels of training, so data were collapsed across groups. Multivariate modeling of pretest-posttest differences using structural equation modeling (SEM) revealed that individual differences in latent change were reliable for all three constructs. More positive changes in fitness were associated with more positive changes in tissue density (i.e., more negative changes in mean diffusivity), andmore positive changes in tissue density were associated with more positive changes in volume. We conclude that fitness-related changes in hippocampal volume may be brought about by changes in tissue density. The relative contributions of angiogenesis, gliogenesis, and/or neurogenesis to changes in tissue density remain to be identified. (C) 2015 Elsevier Inc. All rights reserved.
dc.language.isoen
dc.publisherElsevieren
dc.relation.ispartofNeuroimage
dc.subjectAging
dc.subjectFitness
dc.subjectPhysical exercise
dc.subjectHippocampal volume
dc.subjectHippocampal microstructure
dc.subjectLatent difference modeling
dc.subjectGrowth Curve Modelsen
dc.subjectIndividual-Differencesen
dc.subjectCell-Proliferationen
dc.subjectPhysical-Exerciseen
dc.subjectBrain Plasticityen
dc.subjectDentate Gyrusen
dc.subjectNeurogenesisen
dc.subjectDiffusionen
dc.subjectModifiersen
dc.subjectDynamicsen
dc.titleChanges in fitness are associated with changes in hippocampal microstructure and hippocampal volume among older adults
dc.typeArticle
dc.identifier.doi10.1016/j.neuroimage.2015.11.026
dc.identifier.volume131
dc.identifier.startpage155
dc.identifier.endpage161
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